180 degree swing
Ronald Reagan - Reagan was also originally a Democrat and a New Deal supporter, who became a union leader while in Hollywood. He switched parties officially in 1962 and gave a famous quote: “I didn't leave the Democratic Party. The party left me."
Hillary Clinton - In 1964, a very young Hillary Rodham Clinton was one of the Goldwater Girls who campaigned for the Arizona Republican. She officially became a Democrat later in the 1960s after she attended the 1968 GOP convention.
Leon Panetta - Panetta started out in politics as a Republican and he worked briefly in the Nixon administration. He switched parties in 1971 over concerns about the civil rights policies of the Nixon administration.
Elizabeth Warren - The current liberal icon started life as a conservative who voted Republican because of the party’s pro-business stance, and she didn’t switch to the Democratic Party until the mid-1990s.